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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are often characterized by a focus on the practical aspects of the research design, like the recruitment and consent process, adherence, and the use of routinely available equipment.

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Pragmatic is a software company, offers a variety of casino games to online gambling platforms. Pragmatic's iGaming solutions are utilized by the top operators and casinos with a physical location. The company offers front-end website design tools, analysis and marketing, promotions security payment systems, customer service and bug-reporting. Additionally, the company offers its players a secure environment with high-quality graphics and gaming.

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RTP

Pragmatic Play is one of the top iGaming providers and provides players with a vast portfolio of slot games. Some of these games have high RTPs which allow players to maximize their potential to win. Many of the games are mobile compatible which means they are suitable for tablets and smartphones. Some of these games include a bonus round that allows players to earn free spins.

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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However too much heterogeneity could cause issues with the design of the trial.

Pragmatic Play is also a major player on the live casino market, providing an extensive selection of table games like as Blackjack and Roulette in a variety of versions. The live studios of the company in Romania and Malta provide a genuine gambling experience for customers, as well as a wide range of virtual betting options. The company also has several game shows which make online gambling fun and interactive. Some of these shows have live hosts, whereas others are hosted by prominent personalities from the industry.

Mobile compatibility

Pragmatic Play is a relatively new player in the online casino industry however, it has already earned a name by offering mobile-friendly slots. Their games are optimized for mobile phones, and run on HTML5 technology. They are also licensed and regulated by reputable gaming authorities, ensuring fairness and transparency. This is a great sign for players as it means the games have been tested and verified in order to guarantee the randomness and impartiality of every game.

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Legality

Pragmatic Play is renowned for its top-quality games and also for providing an outstanding user experience. The software is available on mobile devices as well as in various languages. It has been recognized as one of the leading gaming platforms in the casino industry despite its relatively young age. The most recent releases include Wolves, a 5-reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by policymakers and practitioners to inform their decisions. They also provide a useful way to identify the causality between an intervention and its results. However, they should not be used as a substitute for explanation trials.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate a physiological or clinical hypothesis as well as pragmatic trials that inform the policy and practice of. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a practical trial which includes the recruitment process, the design and delivery of the intervention, as well as the follow-up.

There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.