Vardenafil, sildenafil, and tadalafil belong to a class of erectile dysfunction drugs called PDE5 inhibitors. They work by blocking the enzyme PDE5 in the penis. After the erection, the messenger PDE5 releases the signals that cause an erection. The drugs also have different side effects, and some men use a combination of both to improve their sex lives. Although some patients with diabetes are included in placebo-controlled ED studies, results are not usually reported specifically for this population. However, Bell and associates reported a response rate of 36% among 33 men with ED and diabetes. The response rate was related to patient age: only one patient in 14 men over 60 years of age responded to sildenafil. The researchers concluded that sildenafil improved erections in 57% of the patients. When taking sildenafil, it's important to remember that alcohol and other medications can affect blood pressure levels. Drinking excessively while taking this medicine can lead to headaches and dizziness. Additionally, sildenafil(Fildena 50, Fildena double) and tadalafil can interact with other blood pressure-lowering medicines such as aspirin. It's vital to tell your doctor about any medicines you take and consult a pharmacist if you have any questions.