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The NLRP3 inflammasome is important in the development of arthritis, as over-activation of this pathway appears to be a driver of the disease . The NLRP3 inflammasome is an important part of our innate immune systemwhich functions as the body’s immediate defense against external and internal threats. Activation of the NLRP3 inflammasome occurs in the presence of Pathogen Associated Molecular Proteins , or “foreign invaders”.

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