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Methadone works by binding to the same opioid receptors in the brain and spinal cord that are activated by other opioids. However, because methadone has a long duration of action and is taken orally, it can help prevent withdrawal symptoms and reduce the euphoric effects of other opioids, thereby helping individuals break the cycle of addiction. In the treatment of chronic pain, methadone may be used when other opioid medications have been ineffective or are no longer providing adequate pain relief. It is typically reserved for patients who have developed tolerance to other opioids or who require long-term pain management.


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