ED is treated with generic Cialis 20mg, which contains tadalafil. Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, increases penile blood flow during sexual stimulation, helping men get and keep an erection. During sexual stimulation, nitric oxide is released in the penis' erectile tissue, causing cyclic guanosine monophosphate synthesis. The smooth muscles of the penile arteries relax with cGMP, increasing blood flow. When PDE5 breaks down cGMP, the penis becomes flaccid again. Tadalafil inhibits PDE5, reducing cGMP breakdown. This maintains cGMP levels, relaxes penile blood vessels, and extends sexual response.

Generic Cialis 20mg causes results within 30 minutes to 2 hours and lasts up to 36 hours, earning the nickname "the weekend pill. It should be used under medical supervision to evaluate dosage and suitability based on individual health concerns. Like many medications, it may cause negative effects and interact with others. Consult a doctor for safe and effective use.