Fildena, containing sildenafil citrate, is primarily used to treat erectile dysfunction. It works by increasing blood flow to the penis through the inhibition of the enzyme phosphodiesterase type 5 (PDE5). However, Fildena has several important drug interactions to be aware of.

One of the most critical interactions is with nitrates (such as nitroglycerin), commonly prescribed for chest pain or heart conditions. Combining Fildena with nitrates can cause a dangerous drop in blood pressure, leading to fainting, stroke, or heart attack. Similarly, using Fildena with alpha-blockers, often prescribed for prostate problems or hypertension, may also cause significant hypotension.

Other interactions include certain antifungal medications (like ketoconazole), antibiotics (such as erythromycin), and HIV protease inhibitors, which can increase sildenafil levels in the blood and heighten the risk of side effects.

Patients should always inform their healthcare provider about all medications they are taking before starting Fildena to avoid these potentially serious interactions.