almost 3 years ago

The microbes that inhabit hot springs and hydrothermal vents have long fascinated scientists for their ability to survive temperatures in excess of 100 °C. Now these "extremicting attention. For another reason: They may have clues to longevity in much more complex organisms. This includes people.

Researchers have found a genetic mutation that prevents the สมัครสมาชิก SLOTXO ใหม่รับเครดิตฟรี ไม่ฝาก ไม่แชร์ protein-making machinery of these tiny organisms from making mistakes. It can extend the lifespan of flies, worms and yeasts designed to have the same DNA alterations. These findings suggest errors in protein synthesis may be a key driver of aging. and is the goal of future medicines that promote healthy aging.

This study is "It's a "paradigm shift" in the way we think about the causes of aging, says Vera Gorbunova, a molecular biologist at the University of Rochester, who was not involved. important for a longer life span.Numerous studies on the causes of aging and various diseases It has focused on the accumulation of mutations in genes—blueprints for cellular proteins and other molecules, says University College London biologist Ivana Bjedov,

who led the new work. Few consider the flaws in the translation of each blueprint. which can create faulty proteins “I always regret a little protein.

The key to translation is ribosomes, which are cellular mechanisms that use the instructions of DNA to assemble amino acids into proteins. When do bosomes make mistakes? The resulting protein may not fold incorrectly. clings to other proteins and can sometimes damage cells (Misfolded or combined proteins have been implicated in Alzheimer's disease. Parkinson's disease, etc.), cells often find and eliminate faulty proteins. But this maintenance process will come to a halt as we age.

So will fewer translation errors lead to longer life? until the present study “There is no proof that you can raise animals. Improve translation accuracy and make them live longer,” Corbunova said.Bjedov and her team looked for a part of the ribosome known to be important for precise translation: a protein called RPS23, while analyzing genetic information from species throughout the tree of life. From cows to intestinal microbiota The researchers found that the same amino acid occupies a key location in this ribosome protein. But there is an exception: