How Does Leptitox Supplement Work to promote a healthy weight loss? When your body craves more for food and unable to control hunger, this is the point where the problem starts. It is also known as leptin resistance which may lead to obesity and weight gain. When you eat food the excess energy is converted into the fat and stored in fat cells. These fat cells when expand give a signal to the body by releasing leptin, to stop eating. This is the natural cycle, right? But some complications caused by environmental toxins interrupt the signal hence your brain never gets a sign from fat cells because they are unable to release leptin causing leptin resistance.