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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are typically focused on practical aspects of the study design, including the recruitment process and consent in adherence, as well as the use of routinely available equipment.

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Pragmatic Software, a software firm, offers a variety of casino games to online gambling platforms. Pragmatic's iGaming software is used by top operators and land based casinos. The company offers front-end website design tools, analysis and promotions, marketing, security, payment systems, customer service and bug-reporting. Additionally, the company provides its players a secure environment with high-quality graphics as well as gaming.

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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid and also helps to reduce bias in the results. However too much heterogeneity could result in issues with the design of the trial.

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Pragmatic Play has gained a reputation for offering top-quality games and an outstanding user experience. Its software can be used on mobile devices as well as in various languages. Despite its infancy, it has already established itself as a top gaming platform for casinos. Wolves is one of the most recent releases, a 5-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. Usually, they are commissioned by policymakers and practitioners in order to inform their decisions. They can also be used to assess the causal relationship between an intervention with its outcomes. However, they should not be used to replace explanation studies.

The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they are a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the features of a practical trial that include the recruitment process, the design and delivery of the intervention, as well as monitoring.


There is a positive increase in the number pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to remember, however, that the majority were conducted in primary-care settings.