Anobliss Cream 30 gm is a combination of two different drugs, namely Lidocaine (local anaesthetic) and Nifedipine (calcium channel blocker), used in the treatment of Anal fissure (tear in the lining of the anus). An anal fissure is usually a small tear or cut in the lining of the anus. This crack in the skin is responsible for causing extreme pain and bleeding during and after bowel movements. Sometimes these fissures can be deep enough to cause spasms in the anal sphincter, which is the end part of the anus. A person dealing with anal fissures may experience pain during/ after a bowel movement, bleeding during the stool, and a visible crack around the anus area. Lidocaine is a local anaesthetic. It blocks pain signals from the nerves to the brain, decreasing the pain sensation. Nifedipine is a calcium channel blocker (CCB). It works in anal fissures by blocking the action of calcium on the blood vessels of the anus. Altogether the Anobliss Cream 30 gm works by relaxing the smooth muscles around the anus area and promoting the proper blood flow in that region that helps to heal the fissure quickly. Anobliss Cream 30 gm also reduces the anal canal pressure, which diminishes the pain and spasm in the anal region. Anobliss Cream 30 gm should be applied inside the rectum area as suggested by the doctor with the help of a rectal applicator given with the medication. Gently insert the applicator tip, just 1/2 to 1 inch consisting of medication, into the rectum and squeeze the tube to deliver the drug before taking it out. Before using this medicine, clean the affected area with gentle soap and water, and pat dry. Use the applicator for single use and discard it after every use. Never re-use it and use it regularly at the same time each day. Many persons using this drug does not face any side effect; however, possible side effects of Anobliss Cream 30 gm may include burning, itching, redness, irritation, etc. However, if a person notices rectal bleeding, skin redness, or any other serious side effects, they need medical help immediately. The usage of Anobliss Cream 30 gm is not allowed in patients who are hypersensitive to any of the components present in it as it may cause serious side effects. Before starting the medication, tell your doctor about your medical history, especially if you have broken skin/infection in the area where Anobliss Cream 30 gm is to be applied, heart disease, liver disease, or a certain blood disorder (methemoglobinemia). Inform your doctor before taking Anobliss Cream 30 gm if you plan to get pregnant, are pregnant, or breastfeeding. Uses of Anobliss Cream 30 gm Anal fissure (tear in the lining of the anus) Medicinal Benefits Anobliss Cream 30 gm consists of two drugs, namely Lidocaine and Nifedipine. Lidocaine belongs to the class of local anaesthesia and is used to diminish inconvenience or pain associated with anal fissures. Being a sedative, it works by causing temporary loss of sensation in the anal region. It does so by blocking both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions, further reducing depolarization with the resultant blockade of conduction. This way, the person gets relief from the pain associated with rectal discomfort. While Nifedipine works by relaxing the smooth muscles around the anus and promoting the blood in the anal area that helps heal the anal fissure faster. Nifedipine also blocks the action of calcium on the blood vessels of the anus. These actions reduce anal canal pressure, relieving pain and spasm. In this way, the Anobliss Cream 30 gm helps in healing anal fissures. Directions for Use Before using Anobliss Cream 30 gm, clean the affected area with gentle soap and water. Then rinse, and pat dry the area. Anobliss Cream 30 gm comes with single-use wipes to clean the affected area. Gently fill the medication in the applicator and insert it just 1/2 to 1 inch inside the anus area. Also, apply the drug to the anal opening as suggested by the doctor. Discard the applicator after every single use and never reuse it. Never apply this medication with your finger; only use the applicator. To apply the medicine to the outside region of the anus, one should apply a small amount of drugs to the affected area by gently rubbing it. Wash the hands immediately after using the medicine in the affected region. Avoid the contact of the Anobliss Cream 30 gm with the nose, ears, eyes, or mouth. Apply this drug regularly to get the utmost benefits. Seek medical help if your condition does not improve with time or worsens after one to two weeks. Storage Store in a cool and dry place away from sunlight Side Effects of Anobliss Cream 30 gm Application site reactions Tingling sensation Alterations in temperature sensations Swelling Itching Rash.